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Beginning January 1, 2019, Schedule II substances must be prescribed electronically in Arizona and controlled prescriptions must be reported to Arizona's Prescription Monitoring Program (PMP).

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Governor Malloy signed House Bill 7052, An Act Preventing Prescription Opioid Diversion and Abuse, which will go into effect on January 1, 2018. By this date, all controlled substances must be prescribed electronically.

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Illinois joins other states passing a law that requires all medication, non-controlled and controlled substances (CII-CV), to be electronically prescribed. The government even requires medical devices to be e-Prescribed. This law will go into effect January 1st, 2022.


Maine’s e-Prescribing mandate went into effect July 1st, 2017 requiring all prescribers to report prescriptions for controlled substances to Maine’s Prescription Monitoring Program (PMP) as well as be transmitted electronically

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Massachusetts has taken a previously written bill and modified it to new standards in regards to mandating E-Prescribing of Controlled Substances. The changes included exceptions and waivers for providers. The bill requires EPCS as well as other requirements to address opioid addiction. The bills go into effect two years after they are passed, January 1st, 2020.


Minnesota was the first state to mandate e-Prescribing on January 1, 2011. Since then there has been a steady incline of e-Prescriptions in the state, but since there is no enforcement of this mandate, paper prescriptions are still used. Drug overdose deaths in Minnesota increased 11% from 2014 to 2015, proving that there is work to be done. EPCS should be used to improve these numbers.

New Jersey

New Jersey Providers have already been exposed to New York’s strict EPCS mandate, so the government has drafted a bill that also requires all medications, non-controlled and controlled (CII-CV) substances, must be electronically prescribed. The bill also requires EHR vendors to allow EPCS for CII’s. There is no official mandate date, but it will be set for one year after the bills are passed.

New York

New York mandated e-Prescribing of all controlled and non-controlled substances on March 27th, 2016. Since the mandate, thousands of New York prescribers have adopted and e-Prescribing solution.

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North Carolina

North Carolina government has drafted the STOP (Strengthen Opioid Misuse Prevention) Act requiring e-Prescribing for CII-CV medications. The state has listed the potential exceptions to the law, which goes into effect January 1st, 2020.


Beginning in August 2017, Ohio began implementing new requirements for providers when writing prescriptions and are continuously enacting legislation over the next few years. The newest addition, which went into effect on December 29, 2017, required providers to include the first four characters of the ICD-10 diagnosis code or full procedure code on all opioid prescriptions. The law for all other controlled substances goes into effect on June 1, 2018.

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Out of 14,000 prescribers in Oklahoma, only 8% are utilizing e-Prescribing. Law enforcement believes that e-Prescribing will make it easier for doctors to prescribe and renew controlled medications for their patients in smaller dosages – reducing the need for prescribing large amounts. State senators are interested in the bill and additional legislation to help decrease opioid abuse in 2018.

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Senator Alloway has introduced legislation on February 6, 2017, that will require controlled substances to be electronically prescribed. If this bill passes, paper prescriptions for opioids will no longer be accepted. Alloway hopes that this bill will make doctor shopping and prescription forging tough. This bill will go into effect one year after enactment.

Rhode Island

Effective January 1st, 2020, Rhode Island’s bill takes effect mandating e-Prescribing of controlled substances. There are no existing exceptions or waivers in place yet.


On July 1, 2020, Virginia’s statewide EPCS mandate will go into effect, requiring all prescribers to electronically prescribe controlled substances, rather than write paper prescriptions. This mandate is meant to lower the amount of opioid-related deaths in Virginia.

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